A case of multiple hepatic angiomyolipoma in young woman which was difficult in a preoperative diagnosis

Abstract

Hepatic angiomyolipoma (HAML) is a rare hepatic mesenchymal tumor and is composed of a heterogeneous mixture of adipose cells, smooth muscle cells and vessels. HAML is difficulty in distinguishing from other hepatic tumors because of the variety of imaging according to the coustituent. We reported the case of a 22-year old woman presenting a liver tumor with a diameter of 12 cm in left lobe. Liver function was within normal limit and serum surface antigens for hepatitis B and anti-hepatitis C virus antibodies were negative. We suspected that the liver tumor was hepatic adenoma, hemangioma, focal nodular hyperplasia or angiomyoliopoma and the extended left hepatic lobectomy was performed. Histopathologically, the tumor tissue was mainly composed eosinophilic smooth muscle cells, a few blood vessels and adipocytes and was positively stained with HMB-45 by immunohistochemistry. Multiple nodular lesions shown in the resected specimen were stained with HMB-45 and this case was diagnosed multiple HAML.