Focal nodular hyperplasia-like lesion of progressive type in a patient with congenital hepatic fibrosis: a case report

Abstract

A 46-year-old woman was diagnosed with congenital hepatic fibrosis by histological examination of a liver biopsy specimen in 2001. She was routinely followed up with computed tomography (CT) examinations. She had some liver nodules,but these nodules did not enlarge. In August 2013, dynamic CT revealed a lesion with early arterial uptake in the right hepatic lobe. The nodule enlarged progressively. Histopathological examination of a tumor biopsy specimen revealed a well-differentiated hepatocellular carcinoma. The tumor was treated by chemolipoidolization and radiofrequency ablation therapy. The patient developed acute cholangitis 1 year later, and her liver function deteriorated rapidly. She died of hepatic failure at 47 years of age. After careful re-evaluation of histological findings and additional immunohistochemical study, the diagnosis was revised to be a FNH-like lesion of the progressive type.