A case of simultaneous hepatocellular carcinoma and cholangiocellular carcinoma in a patient with alcoholic liver injury

Abstract

A 79-year-old male patient with hypertension, hyperlipidemia, and chronic alcoholic liver disease was referred to our hospital because an abdominal ultrasound had revealed multiple tumors in the liver.

Abdominal ultrasound revealed hypoechoic masses measuring 30 mm in diameter at S8 and 15 mm in diameter at S6. On contrast-enhanced computed tomography, both these tumors had a high density in the arterial phase, with the S8 tumor showing gradual washout from the portal phase and the S6 tumor showing a delay in the contrast effect up to the equilibrium phase. We performed a subsection of the liver S8 tumor and partial resection of the S6 tumor at our hospital. On histopathological examination, the S8 tumor was diagnosed as mid-differentiated hepatocellular carcinoma and the S6 tumor as cholangiocellular carcinoma. The combination of cholangiocellular carcinoma and hepatocellular carcinoma described in this case report is a rare finding worthy of documentation.