Abstract
We prospectively evaluated liver stiffness (LS), controlled attenuation parameter, and the FibroScan-AST (FAST) score in patients with human immunodeficiency virus (HIV) using transient elastography. The study comprised 166 patients, including 60 (45.9%) patients with hepatitis B antigen positivity, 30 (18.1%) patients with hepatitis C who achieved sustained virologic response by direct-acting antivirals or interferon, and 54 (32.5%) patients with metabolic dysfunction associated steatotic liver disease (MASLD). None of the hepatitis B-positive patients undergoing antiretroviral therapy had no liver cirrhosis (LC), whereas LS was decreased in patients with hepatitis C. LC and hepatocellular carcinoma were found in 5 and 1 patient with MASLD, respectively. The FAST score and LS were significant progression factors leading to death and LC in patients with HIV and MASLD. In conclusion, the risk of progression to LC was higher despite the younger age of patients with HIV and MASLD compared to the general population. LS and the FAST score were significant factors associated with MASLD progression to LC in patients with HIV.
