Familially Observed Delay in Clearance of Plasma Indocyanine Green

Part II: Laboratory Studies and Morphological Examinations of the Liver

Abstract

Laparoscopic, light microscopic and electron microscopic examinations performed on 2 subjects with familial delay of ICG clearance (FDIC) revealed that although no remarkable change was observed macroscopically and light-microscopically, an increase of vesiculated endoplasmic reticulum, widening of inner space in nuclear envelope, tubular inclusions in giant mitochondria and an increase of lipofuscin granules were constant findings on electron micrographs. The pattern of binding of ³⁵S-ICG with serum proteins and the metabolism of I-131 BSP in 3 FDIC subjects were normal. However, an extremely slow rate of hepatic uptake of ICG (a_ICG) was characteristic.