Abstract
In order to clarify the effect of urease inhibitor, acetohydroxamic acid (AHA), caprylohydroxamic acid (CHA) and nicotinohydroxamic acid (NHA) on hyperammoniemia, dogs with Eck fistula and rats with CCl4 hepatic damage associated with hyperammoniemia were use
Clinically, oral administration of CHA was made in 8 cirrhotic patients with hyperammoniemia. The blood ammonia decreased significantly after the oral or intravenous administration of urease inhibitors in the experimental animals, and the decrease of blood ammonia was noted immediately after an intravenous administration. By the oral or intravenous administration of AHA or CHA in experimental rats, hyperammoniemia improved after the decrease of mucosal urease activities. The blood ammonia decreased in 5 out of 8 cirrhotic patients with hyperammoniemia. The effect of urease inhibitors on hyperammoniemia is thought to be systemic and to be brought about by the inhibition of intestinal mucosal urease activities.
