Abstract
The effects of phenobarbital (PB) and bucolome (BC) on dye metabolism (bilirubin, BSP, ICG) were studied in Sprague-Dawley (SD) rats, Gunn rats and mongrel dogs.
Daily administration of both PB (i.m.) and BC (i.p.) for 5 days caused a decrease in the serum bilirubin levels in Gunn rats and an increase in plasma clearance rate of ICG and BSP in both rats. PB caused a significant increase in hepatic glucuronyltransferase activity and Y protein (p<0.01), while BC caused no changes in these values. Intravenous injection of BC was followed by a remarkable increase in portal flow of dogs and bile flow of rats, but PB resulted in no such changes. Binding capacity of serum protein to ICG was more markedly increased by BC than by PB.
It seems that the effects of BC on dye metabolism are due to the increase in hepatic blood flow and bile flow and to the changes in serum protein.
