Effect of ornithine-aspartate and vitamine B₆ on lipid synthesis in ethanol treated mice

Abstract

An increase of blood and liver total cholesterol by ethanol did not affect by the joint use of ornithine-aspartate and vitamine B₆.
However, the joint use of ornithine-aspartate and vitamine B₆ had an inhibitory effect on the increase in biosynthesis of fatty acid and on the decrease in biosynthesis of cholesterol by ethanol.
When ornithine-aspartate or vitamine B₆ alone was administered in normal mice, a decrease in the incorporation of acetate-1-¹⁴C into cholesterol and an increase in the incorporation of acetate into fatty acid were seen.
On the metabolic rate of ethanol, the disappearance rate of blood ethanol is more rapid in the ornithine-aspartate treated mice and in mice pretreated with ornithine-aspartate, the metabolic rate of ethanol in liver was higher.
From the above result, it may be said that the joint use of ornithine-aspartate and ornithine-aspartate plus vitamine B₆ normalize partially ethanol induced liver lipid synthesis.