Abstract
Here is reported a clinicopathological course of an interesting case of acute hepatitis type-B (a d r). The case was a 25-year old male who appeared to be infected in the laboratory where a large amount of the HBs antigen positive blood treated. He was turned to be positive for HBs antigen by the routine periodic examination, and at this stage his liver function tests were quite normal. When he was admitted to the hospital and observed, typical hepatitic symptoms and abnormal liver functions were found out. HBs antigen showed the peak about 10 days prior to the peak of S-GPT, and also disappeared about 10 days, preceding S-GPT normalized. S-GPT remained abnormal for about 40 days successively. e antigen was detected transient around the peak time of HBs antigen; anti HBc was detected about 10 days prior to the negative change of HBs antigen, and a rather low titer was continuously kept. According to the orcein stained samples obtained by the liver biopsy at the active stage and the recovery stage of hepatitis, HBs antigen was mainly observed in the cytoplasm of liver cells, distributed mostly in the middle and peripheral zones of liver lobulus, and was focal distribution type.
