Inhibitory effect of sulfobromophthalein (BSP) on the hepatic uptake and biliary excretion of ^99mTc-pyridoxylideneisoleucine (Pi) in rats

Abstract

Plasma clearance and biliary excretion of an iv injected ^99mTc-pyridoxylideneisoleucine (Pi) were compared in control rats and in rats excreting sulfobromophthalein (BSP) into the bile at a maximal rate (Tm). Both plasma clearance and biliary excretion of ^99mTc were delayed in rats made in a BSP Tm state compared with control rats. However, when the data were compared with the results previously reported for ^99mTc-N-2, 6-(dimethylphenylcarbamoylmethyl) iminodiacetic acid (HIDA, K. Kitani, et al., Jap. J. Nucl. Med. 15: 999, 1978), the inhibitory effect of BSP was less prominent on biliary excretion and conversely, more striking on plasma clearance for ^99mTc-Pi.