Abstract
Relationships between Hepaplastintest, prothrombin time, albumin, γ-globulin, GPT, and the effective hepatic blood flow of 198Au-colloids as a measure of effective hepatic blood flow were studied by correlation analysis, in 50 patients with liver diseases, including chronic hepatitis or cirrhosis. Simple correlation coefficients were highly significant between Hepaplastintest, prothrombin time, albumin, and the effective hepatic blood flow; however, not between GPT or γ-globulin and the other parameters. Further correlation analysis revealed a highly significant partial correlation coefficient between Hepaplastintest and albumin and the effective hepatic blood flow; however, not between Hepaplastintest and albumin. As effective hepatic blood flow is considered to be proportional to the liver parenchymal volume, the above results indicate that vitamin-K-dependent clotting factors, as well as albumin, reflect the liver cell mass.
