Abstract
It is known experimentally that glucagon and insulin have synergistically promotive effect of liver cell regeneration, which are called hepatotrophic factors in portal venous blood. On this basic assessment, we applied clinically glucagon and insulin infusion in the treatment of acute liver failure. 1 mg glucagon and 10 units regular insulin were dissolved in 500ml of 5% glucose solution and aromatic aminoacids-free aminoacid solution Was continuously administered.
Clinical assessment, blood chemistry, hepaplastin test, rapid turnover proteins, and alphafetoprotein were examined on admission, at the beginning and the end of this therapy. Among 15 patients of acute liver failure, 5 patients have been relieved and the other 2 patients have recovered from hepatic coma.
In the early diagnosis of acute liver failure, hepaplastin test and rapid turnover proteins were good parameters, while alpha-fetoprotein was valuable parameters of liver regeneration, so far.
