Abstract
The investigation was undertaken to know ultrastructural changes of experimentally induced fatty livers. When subcellular organelles involving in lipid metabolism are loaded with excess of lipid, they float to a lighter fraction than an original fraction. Therefore, the lighter fraction might reflect pathogenesis of fatty livers.
The heavy subfraction of the floating lipids studied consisted of intermediate particles between storage lipids and organelles such as microsomes, Golgi and lysosomes. Membraneenclosed particles, originated in the above mentioned organelles, were large in size(Ca 0.4μ), whilc membrane free particles, probably presursors of storage lipids and secretory VLDLs, were small in size(less than 0.1μ). Fatty changes due to impaircd protein synthesis by carbon tetrachloride was characterixed by VLDL-free Golgi vacuoles. Ethanol-induced fatty changes followed a remarkable increase of Golgi derived dense bodies filled with VLDLs.
