Serological diagnosis of acute hepatitis A

Abstract

Diagnostic usefulness of modified competitive binding radioimmunoassay using protein A for the detection of immunoglobulin M (IgM) to hepatitis A virus (HAV) was studied in acute hapatitis A patients sera.
1) Diagnosis of hepatitis A was firmly made as a G index which is the ratio of IgG treated cpm to non treated cpm showing to be less than 2.0.
2) An IgG treated procedure was more reliable than an IgM treated one for the diagnosis of hepatitis A in the early acute phase sera of the illness.
3) Our study suggested the presence of IgG anti-HAV in early acute phase serum of hepatitis A.