Abstract
To ascertain a promoting factor of glucose intolerance and abnormal insulin response in liver disease, insulin binding to peripheral mononuclear cells was compared with results of 100g-OGTT and insulin sensitivity index (ISI). A half ng per ml of 125I-insulin specific binding to 107 cells was tested in 14 normal subjects and 49 with liver disease.
In liver disease, peripheral insulin activity (A) and ISI were decreased. Insulin binding in normal was 1.03±0.57%, and decreased significantly in liver disease (p<0.01). Scatchard plots revealed that the decrease in liver disease was owing mainly to reduced binding sites. Significant correations were found between insulin binding and ISI or A.
In conclusion, the reduced insulin receptor may have a significant role for the progression of glucose intolerance in liver disease.
