Abstract
We examined the effects of glucose administration on the recovery of galactosamine induced acute liver injury of rats, by giving either orally or subcutaneously. The survival rate was higher in oral glucose administration group (oral group) than in subcutaneous glucose administration group (subcut. group). Histologically the liver repaired in oral group but not in subcut. group, at 72 hours after galactosamine treatment. The difference in gluose concentration between portal and peripheral vein was significantly higher in oral group than in subcut. group, suggesting that oral glucose administration rather than subcutaneous increased hepatic glucose uptake. Regional hepatic blood volume and oxygen consumption measured by reflectance spectrophotometry and ATP level in the liver were increased by oral but not by subcutaneous glucose administration. The results suggest that oral glucose administration is more effective on the recovery of galactosamine induced acute liver injury than subcutaneous glucose administration.
