Experimental study on galactose tolerance test as a test for functional reserve cell mass of the liver comparison with ICG Rmax

Abstract

In previous clinical study, we found that the dissociatin between the estimation of galactose tolerance test and ICG Rmax in patients with various liver diseases.
In this paper, galactose tolerance test by rat livers before and at intervals after partial hepatectomy and D-galactosamine (GaIN) injection was compared with ICG Rmax in an attempt to stlldy the correlation between the pathological state of the liver and estimation of tests for functional reserve cell mass of the liver. ICG Rmax paralleled with changes in liver weight after hepatectomy and GaIN injection at intervals for 7 days.
On the other hand, galactose tolerance test did not paraller with changes in liver weight after partial hepatectomy and GaIN injection and rather depended on functional defect of the liver cell due to liver cell necrosis after GaIN injection.
There was indicated that it was the main reason of the dissociation between the setimation of galactose tolerance test and ICG Rmax in clinical study that liver weight never correlated with functional cell mass of the liver.