HBs抗原キャリアーに重感染したA型急性肝炎症例の検討:特にHBV関連抗原の組織免疫学的検討

樋口 清博; 小島 隆; 青山 圭一; 松井 俊二郎; 康山 俊学; 紺田 健彦; 柴田 貢; 市田 隆文; 中野 護; 井上 恭一; 佐々木 博; 井本 勉

doi:10.2957/kanzo.24.149

Immunohistochemical investigation of hepatitis B virus (HBV) associated antigens in liver tissues in asymptomatic HBs antigen carrier associated with simultaneous hepatitis A virus (HAV) infection

Kiyohiro HIGUCHI, Takashi KOJIMA, Keiichi AOYAMA, Shinjiro MATSUI, Toshihumi YASUYAMA, Takehiko KONDA, Mitsugu SHIBATA, Takafumi ICHIDA, Mamoru NAKANO, Kyoichi INOUE, Hiroshi SASAKI, Susumu IMOTO

Author information

Kiyohiro HIGUCHI
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Takashi KOJIMA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Keiichi AOYAMA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Shinjiro MATSUI
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Toshihumi YASUYAMA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Takehiko KONDA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Mitsugu SHIBATA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Takafumi ICHIDA
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Mamoru NAKANO
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Kyoichi INOUE
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Hiroshi SASAKI
The 3rd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
Susumu IMOTO
Department of Internal Medicine, Kobe Shinko Hospital

JOURNAL FREE ACCESS

1983 Volume 24 Issue 2 Pages 149-160

DOI https://doi.org/10.2957/kanzo.24.149

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Abstract

In three asymptomatic HBs antigen carriers infected with HAV the changes of serum HBV associated antigen and antibody system and HBV associated antigens in liver tissue were investigated.
1) In serum, HBs antigen titer was low in acute phase of superimposed type A viral hepatitis and increased in recovery phase. Anti-HBc titer showed no similar changes. HBe antigen and anti-HBe revealed almost the same level throughout the course.
2) In liver tissue, HBs antigen positive hepatocyte was rare or disappeared in acute phase of superimposed type A viral hepatitis and increased distinctly in recovery and healing phase. One case revealed marked membranous localization of HBs antigen in recovery phase. HBc and HBe antigens were rare in acute phase and increased in healing phase in serum HBe antigen positive case.
3) It is suggested that the changes of HBs antigen titer in serum reflected amounts of HBs antigen produced in liver tissue. However, changes of serum HBe antigen titer and amount of HBe antigen in hepatocytes showed no pararell relation.

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