Remarkable regression of hepatocellular carcinoma by reduced glutathion: A case report

Abstract

A case of hepatocellular carcinoma (HCC) snccessfully treated with reduced glutathion (GSH) was reported. A 59 year-old female was admitted to our department due to hepatomegaly. Serum AFP was 11357.5ng/ml, and angiogram, CT scan and echogram disclosed the presence of HCC (diffuse type) which was subsequently confirmed by liver biopsy. These tumors occupied more than 50% of the whole liver and surgical intervention was not indicated. Oral GSH therapy, experimentally suggested effective for HCC by Novi, was applied to this patient and she has been followed up for 18 months at the outpatient clinic by liver function test, serum AFP, echogram and CT. Three months after the beginning of GSH administration, remarkable decrease of AFP was observed with general improvement and disappearance of tumors in the liver on CT and echogram. Eighteen months after GSH treatment started, the tumors have regressed to below 5% of the whole liver on CT and this patient has fulfilled perfect social rehabilitatiom. This is the first clinical report of snccessful treatment of HCC by GSH, and the meckanism of GSH to HCC was also discussed.