Comparison of the effectiveness of oral and subcutaneous glucose treatment on energy metabolism in the liver of rats with galactosamine induced acute liver injury

Abstract

We compared the effects of oral (oral group) and subcutaneous (subcut. group) administration of glucose on energy metabolism in the liver of rats with galactosamine induced acute liver injury. There was no difference in plasma glucose level between oral group and subcut. group. Hepatic glucose was higher in subcut. group than in oral group, but hepatic glucose-6-phosphate and hepatic glycogen were not different in both group. In oral group, hepatic ATP content and energy charge were significantly elevated, and were higher than in subcut. group. In subcut. group, hepatic ATP content was not changed after glucose administration, and the increase of energy charge was delayed.
These results suggest that oral glucose treatment is more effective on the glucose utilization and energy metabolism in the liver or rats with galactosamine induced acute liver injury.