Clinical study on hepatic extraction rate of ICG in patients with portal hypertension

Abstract

Hepatic extraction rate of ICG (ER) was measured by the technique of the hepatic vein catheterisation and single injection method of ICG of 0.5mg per body weight kg in 91 patients with esophageal varices, that consisted of 70 patients with cirrhosis and 21 with idiopathic portal hypertension. All of them underwent the direct interruption surgery.
ER in cirrhosis (46.3%)was lower than that in idiopathic portal hypertension (60.1%) and that in control (75.9%). ER was correlated with K-ICG, estimated hepatic blood flow, wedged hepatic vein pressure and weight of excised spleen, but not correlated with portal pressure. ER was correlated with several hepatic function tests (A/G, γ-G, ZTT, Ch-e). Moreover ER showed a significant correlation with magnitude of post-operative change of K-ICG level.
ER was considered useful in determining operative indication and also predicting postoperative prognosis in patients with esophageal varices.