1987 Volume 28 Issue 3 Pages 291-296
The effects of OK-432 (streptococcal preparation) on murine fluminant hepatitis were investigated. Hepatitis was induced by injection of mouse hepatitis virus type 2 (MHV-2) at a strength of either 1×103 or 1×104 plaque forming units (PFU). Mice without OK-432 treatment died Within five days, whereas after 60 days mice preinoculated With OK-432 showed survival rates of 50%(1×103 PFU) or 10% (1 × 104 PFU). Survival time was not prolonged if OK-432 was injected after MHV-2. Examined histologically mice untreated with OK-432 showed severe hemorrhagic necrosis of the liver, often panlobular. Treated mice showed less necrosis; the least necrosis was observed in those injected with OK-432 before MHV-2. In 7-day survival mice injected first with OK-432 and then with 1×103 PFU of MHV-2, autopsy showed a very slight and focal hepatic necrosis with follicular infiltration by lymphocytes and macrophages.
