Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
The changes of cell kinetics of uni-and binucleated hepatocytes after partial hepatectomy in DEN induced chronic liver injured rats
JUNG ROU TsaiTakafumi YAMASHITAHiroaki YOSHINOYasuko YAMADAKazuhiko YOSHIKAWATetsuro ISHIKAWAMasaichi OHIRATakashi AZUMAKaoru UMEYAMA
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1989 Volume 30 Issue 12 Pages 1702-1708

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Abstract
We produced diethylnitrosamine induced chronic liver injury in rats. These rats were divided morphologically into two groups: liver fibrosis and liver cirrhosis group. Then we examined cell kinetics of uni- and binucleated hepatocytes after hepatectomy (Hx) using antibromodeoxyuridine monoclonal antibody. The values of labeling indices (LIs) of uninucleated hepatocytes in liver fibrosis group were higher than those in liver cirrhosis one. But the values of LIs of binucleated cells in both groups after Hx were lower than those in normal liver.
From the above results, it is suggested that binucleated hepatocytes in chronic injured liver do not participate in liver regeneration.
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© The Japan Society of Hepatology
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