Abstract
We experienced siblings who were born to an anti-HBe positive HBV carrier mother and suffered from chronic liver dysfunction. The senior sister developed severe hepatitis type B at two month of age. But moderate liver dysfunction persisted for 12 months after positive conversion of HBs antibody. It was suggested that she had been transmitted HBV and Non-A, Non-B hepatitis virus (NANBV) concomitantly at birth. Her junior brother was administrated hepatitis B hyper-immunoglobulin just after birth to block of mother-to-infant transmission of HBV. But he also suffered from chronic liver dysfunction after two months for 11 months. HBs antibody elevated and HBc antibody reelevated spontaneously from 8 months after birth. It may also be possible that NANBV prolonged the incubation time of HBV.
