Experimental study on extension of resectability of the liver with administration of testosterone in dogs, with special reference to pathophysiology of the remnant liver and effects of testosterone

Abstract

Four-week survival rate after 84% hepatectomy in dogs was improved from 22.2% to 46.6% with preoperative administration of testosterone.
Fatty infiltration, mainly with triglycerides and always apparent in the remnant liver at an early period following major hepatectomy, was reduced with administration of testosterone, which also resulted in a decrease in lipid peroxide formation.
The activity of catalase in the remnant liver markedly decreased following 84% hepatectomy, but with administration of testosterone, no significant decrease was recognized.
Results of the present study suggest that testosterone administered prior to extended hepatectomy reduces fatty infiltraiton and may prevent injury to remnant liver cells caused by lipid peroxides and free radicals. Thus the long term prognosis is improved following 84% hepatectomy in dogs.