B型肝炎ウイルス(HBV)感染肝細胞障害過程における肝門脈域CD4/CD8細胞比,肝実質域CD8/CD5細胞比に関する検討

佐多 斉; 銭谷 幹男; 坂口 正巳; 奥山 早苗; 河辺 朋信; 根岸 正史; 宮崎 寛; 出浦 正倫; 大越 裕文; 安藤 秀樹; 清水 能一; 亀田 治男; 田中 貢

doi:10.2957/kanzo.31.1143

Study on CD4/CD8 in liver portal area (Po-L3/T8) and CD8/CD5 in parenchyma (Pa-T8/T1) of liver cell injury on hepatitis B virus (HBV) infection

Hitoshi SATA, Mikio ZENIYA, Masami SAKAGUCHI, Sanae OKUYAMA, Tomonobu KAWABE, Masashi NEGISHI, Hiroshi MIYAZAKI, Masanori DEURA, Hirofumi OOKOSHI, Hideki ANDO, Yoshikazu SHIMIZU, Haruo KAMEDA, Mitsugu TANAKA

Author information

Hitoshi SATA
First Department of Internal Medicine, The Jikei University School of Medicine
First Department of Pathology, The Jikei University School of Medicine
Mikio ZENIYA
First Department of Internal Medicine, The Jikei University School of Medicine
Masami SAKAGUCHI
First Department of Internal Medicine, The Jikei University School of Medicine
Sanae OKUYAMA
First Department of Internal Medicine, The Jikei University School of Medicine
Tomonobu KAWABE
First Department of Internal Medicine, The Jikei University School of Medicine
Masashi NEGISHI
First Department of Internal Medicine, The Jikei University School of Medicine
Hiroshi MIYAZAKI
First Department of Internal Medicine, The Jikei University School of Medicine
Masanori DEURA
First Department of Internal Medicine, The Jikei University School of Medicine
Hirofumi OOKOSHI
First Department of Internal Medicine, The Jikei University School of Medicine
Hideki ANDO
First Department of Internal Medicine, The Jikei University School of Medicine
Yoshikazu SHIMIZU
First Department of Internal Medicine, The Jikei University School of Medicine
Haruo KAMEDA
First Department of Internal Medicine, The Jikei University School of Medicine
Mitsugu TANAKA
First Department of Pathology, The Jikei University School of Medicine

JOURNAL FREE ACCESS

1990 Volume 31 Issue 10 Pages 1143-1151

DOI https://doi.org/10.2957/kanzo.31.1143

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Abstract

The relation between positive cell ratio of HBV related antigen in hepatocytes and the disribution of lymphocyte subpopulation was studied in biopsied liver of the chronic hepatits B patients. In case both Po-L3/T8 and Pa-T8/T1 were high rate, HBc antigen positive rate was high, view of intensive inflammation were observed in parenchyma and ALT showed the tendency to be high. These results indicate that in case of liver cell injury on hepatitis B virus, Po-L3/T8 reacts to HBc antigen in liver cell and participates in the change of Pa-T8/T1 simultaneously.

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