The in vivo effect of Chinese traditional medicine on alteration of the infection pattern of Duck hepatitis B virus in Chinese carrier ducks

Abstract

To investigate the effect of Chinese traditional medicine on the alteration of infection pattern of Duck hepatitis B virus (DHBV), each seven DHBV carrier duck of six month old was treated with Shen San Chi (2g/kg) and Zhu Lin Duo Tang (40mg/kg) twice a week for six months. The amount of serum DHBV-DNA during the treatment and the degree of hepatitis activity and DHBV sAg in the liver after the treatment were examined and compared to those of ducks treated with Foscarnet and control ducks. All these drugs brought the significant decrease of the amount of serum DHBV-DNA and DHBV sAg in the liver. Hepatitis activity was also reduced by the treatment of these drugs.
Shen San Chi and Zhu Lin Duo Tang seemed to have antiviral effect in vivo on DHBV infection.