Two cases of remarkable retardation of both ICG and BSP excretion

Abstract

Two cases of marked retardation of both ICG and BSP excretion are presented. In both cases, the marked delay in plasma clearance of ICG and BSP was seen, while bilirubin was normal. The analysis of plasma disappearance curves of ICG and BSP suggested that the patients had defect of dye uptake in the hepatocytes. Histological findings were compatible with chronic active hepatitis. The family examinations revealed that two daughters of case 1 and the younger sister of case 2 had abnormal excretion of coloring substances. So, these two cases might have congenital factor of disturbed excretion of ICG and BSP, although the influence of hepatitis could not be completely excluded. These cases seemed to have new type of abnormal mechanism of dye excretion.