B型慢性肝疾患におけるIgM型HBc抗体の分子性状の変化について

辻 邦彦; 長谷部 千登美; 村住 ゆかり; 吉田 行範; 金井 賀子; 大平 基之; 大田 人可; 幸田 弘信; 小野 稔; 矢崎 康幸; 関谷 千尋; 並木 正義

doi:10.2957/kanzo.32.1

Molecular form of IgM antibody to hepatitis B core antigen in sera from the patients with chronic hepatitis B virus infection

Kunihiko TSUJI, Chitomi HASEBE, Yukari MURAZUMI, Yukinori YOSHIDA, Masumi KANAI, Motoyuki OHHIRA, Hitoyoshi OHTA, Hironobu KOHDA, Minoru ONO, Yasuyuki YAZAKI, Chihito SEKIYA, Masayoshi NAMIKI

Author information

Kunihiko TSUJI
The Third Department of Internal Medicine, Asahikawa Medical College
Chitomi HASEBE
The Third Department of Internal Medicine, Asahikawa Medical College
Yukari MURAZUMI
The Third Department of Internal Medicine, Asahikawa Medical College
Yukinori YOSHIDA
The Third Department of Internal Medicine, Asahikawa Medical College
Masumi KANAI
The Third Department of Internal Medicine, Asahikawa Medical College
Motoyuki OHHIRA
The Third Department of Internal Medicine, Asahikawa Medical College
Hitoyoshi OHTA
The Third Department of Internal Medicine, Asahikawa Medical College
Hironobu KOHDA
The Third Department of Internal Medicine, Asahikawa Medical College
Minoru ONO
The Third Department of Internal Medicine, Asahikawa Medical College
Yasuyuki YAZAKI
The Third Department of Internal Medicine, Asahikawa Medical College
Chihito SEKIYA
The Third Department of Internal Medicine, Asahikawa Medical College
Masayoshi NAMIKI
The Third Department of Internal Medicine, Asahikawa Medical College

JOURNAL FREE ACCESS

1991 Volume 32 Issue 1 Pages 1-7

DOI https://doi.org/10.2957/kanzo.32.1

Details

Abstract

Molecular form of IgM antibody to hepatitis B core antigen (IgM anti-HBc) was analysed by high speed liquid chromatography and enzyme-immunoassay in sera from patients with actue and chronic hepatitis B virus infection
IgM anti-HBc was detected in only 19S IgM with both initial stage and recovery stage of acute hepatitis, but it was detected in not only 19S IgM but also 7S IgM with chronic hepatitis.
Furthermore, 19S IgM was predominant in acute exacerbation phase and conversely 7S IgM was predominant in inactive phase of chronic hepatitis.
These findings suggest that the main molecular form of IgM anti-HBc was changed from 7S IgM to 19S IgM with acute exacerbation of chronic hepatitis.

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