1991 Volume 32 Issue 1 Pages 63-66
We recently found that a specific inhibitor of leukotrienes protected from the experimentally induced liver injury, and that the leukotriene C4 directly injured the liver cellsin vitro. It is thought that leukotrienes may play an important role in liver injuries.
We studied about the leukotriene B4 receptor and the leukotriene C4 receptor of isolated rat hepatocytes, in order to analyze the mechanisms of the liver cell injury induced by leukotrienes. As a result, there is no leukotriene B4 receptor, but there is the specific leukotriene C4 receptor in the rat hepatocyte. This result indicates that the leukotriene C4 has some functions against hepatocytes through the binding with specific receptors of hepatocytes.
