Abstract
A 62-year-old woman was admitted to our hospital for evaluation of liver dysfunction with a positive antimitochondrial antibody determination. The hepatic biopsy revealed chronic nonsuppurative destructive cholangitis which was compatible with Scheuer's stage 2 of primary biliary cirrhosis (PBC). One year after the diagnosis of PBC, she complained of lumbago and was diagnosed as Bence Jones (BJ) kappa type multiple myeloma (MM) because of compression fractures of the lumbar vertebrae, BJ proteinuria with monoclonal BJ-κ type protein by immuno-electrophoresis and 63.4% abnormal plasma cells by a bone marrow aspiration. PBC associated with MM is very rare and only 5 cases have been reported. In this paper, we have reported the first case of PBC associated with BJ type of MM, who received a successful treatment with recombinant interferon alpha 2b. We have discussed a possible mechanism for these two patho-logical conditions in the retrospective aspect of long term observation.
