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This paper discusses the availability of LES on the wind-resistant design for buildings in cities. In order to predict the wind pressures and forces on actual complicated-shaped buildings with good accuracy, we introduce the unstructured-grid system which is formulated on the open source CFD code. Especially the hybrid method is employed consisting of the Cartesian grid for the accurate turbulence structures in the urban canopy, and the unstructured-grid for the accurate wake flows around the specified building inside the densely arrayed buildings in the center of cities. In this study, we apply this method to the wind load estimation of a high rise building in a city at inclined wind direction to the main streets. The obtained results of wind pressure distributions on the surfaces of high-rise building are estimated in comparison with the previous experimental data.