1971 Volume 46 Issue 10 Pages 401-404
Lividomycin has been produced by the Institute of the Kowa Company. The results of basic research of Lividomycin are already reported by the Kowa Company. Antituberculous activity of Lividomycin in vitro has been investigated using Kirchner's half liquid media and 1% Ogawa media in our laboratory.
Bacteriostatic activity against H37Rv-S strain was observed in 0.5 mcg/ml concentration of Kirchner's half liquid media and 25.0 mcg/ml of 1% Ogawa media. The growth of H37RvR-SM strain was inhibited under the same concentration of each media as in the case of H37RvS strain. Bacteriostatic activity against H37Rv-R-KM and H37Rv-R-VM strain, however, was reduced in each media. Bacteriostatic activity against wild strains was observed in each media similar to the preserved strains.
Lividomycin seems to have c ross resistance with Kanamycin, but further studies must be made as a new antituberculous drug.
