Abstract
The effects of cyclophosphamide (CY) on reticuloendothelial system (RES) and immune responsiveness were studied in mice.
1) Single injection of sublethal dose of CY reduced the number of peritoneal cells, but the activity as measured by increased rates of carbon clearance and peritoneal macrophage spreading sustained almost normal immediately after CY injection. Thereafter the activity of RES increased slowly and reached its maximum about 10 days later.
2) CY-pretreatment increased delayed type hypersensitivity (DTH) and decreased the number of plaque forming cells (PFC) to sheep red blood cells immunized 3 days after injection of CY, while thereafter it was found that DTH decreased and the production of PFC increased and reached to a peak about 10 days later.
3) CY-pretreatment reduced a resistance against pseudomonas infection 3 days after injection, while the increased resistance was found thereafter and reached to a peak about 10 days later.
