INDUCTION OF SUPPRESSOR ADHERENT CELLS BY INJECTING HEAVY DOSE OF LIVE BCG
II. The Characterization of Suppressor Adherent Cells
1980 Volume 55 Issue 10 Pages 443-446
Details
1980 Volume 55 Issue 10 Pages 443-446
In the previous report, the present author showed that the suppression by live BCG-pretreatment on delayed-type hypersensitivity is possibly mediated with adherent macrophage-like cells, by the use of the macrophage migration inhibition test.
The present study was undertaken to characterize the adherent cells involved in this suppression.
The result were as follows:
1) The adherent cells from mice injected with live BCG at least 12 days before cell harvest showed the suppressive effect.
2) The suppressive effect of the adherent cells acted beyond the major histocompatibility (H-2) barrier; it was shown both in C3H/He and C57BL/6 mice.
3) The suppressive adherent cells were sensitive to methotrexate but not to cyclophosphamide.
