1986 Volume 61 Issue 12 Pages 627-632
Clinicopathological study of 11 cases of histiocytic necrotizing lymphadenitis was performed. Most of the Iymphadenopathies were found in young females, and they usually developed in bilateral cervival areas. Moderate fever with local tenderness was noticed in all cases. The anti-tuberculous drugs had been administered in three cases and antibiotics in 5 cases, but no effect was shown. The characteristic feature on microscopic findings was the focal necrosis without the infiltration of granulocytes. Ultrastructurally the tubulo-reticular structures were found occasionally in the cytoplasma of histiocytes. However, the aetiology of this disease is still unclear, some investigators emphasised in the past reports that the influence of EB virus infection might be considered.
