DRUG-INDUCED HEPATOTOXICITY CAUSED BY ANTI-TUBERCULOSIS DRUGS IN TUBERCULOSIS PATIENTS COMPLICATED WITH CHRONIC HEPATITIS

Yugo KANEKO; Naohiro NAGAYAMA; Yoshiko KAWABE; Masahiro SHIMADA; Junichi SUZUKI; Makiko KUNOGI; Hirotoshi MATSUI; Masahiro KAWASHIMA; Junko SUZUKI; Haruyuki ARIGA; Nobuharu OSHIMA; Kimihiko MASUDA; Yoshinori MATSUI; Hideaki NAGAI; Atsuhisa TAMURA; Shinobu AKAGAWA; Emiko TOYODA; Kazuko MACHIDA; Atsuyuki KURASHIMA; Hideki YOTSUMOTO

doi:10.11400/kekkaku1923.83.13

Yugo KANEKO, Naohiro NAGAYAMA, Yoshiko KAWABE, Masahiro SHIMADA, Junichi SUZUKI, Makiko KUNOGI, Hirotoshi MATSUI, Masahiro KAWASHIMA, Junko SUZUKI, Haruyuki ARIGA, Nobuharu OSHIMA, Kimihiko MASUDA, Yoshinori MATSUI, Hideaki NAGAI, Atsuhisa TAMURA, Shinobu AKAGAWA, Emiko TOYODA, Kazuko MACHIDA, Atsuyuki KURASHIMA, Hideki YOTSUMOTO

Author information

Yugo KANEKO
Respiratory Department, National Hospital Organization Tokyo National Hospital
Department of Pulmonary Medicine, Jikei University School of Medicine
Naohiro NAGAYAMA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Yoshiko KAWABE
Respiratory Department, National Hospital Organization Tokyo National Hospital
Masahiro SHIMADA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Junichi SUZUKI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Department of Pulmonary Medicine, Jikei University School of Medicine
Makiko KUNOGI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Department of Pulmonary Medicine, Juntendo University School of Medicine
Hirotoshi MATSUI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Masahiro KAWASHIMA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Junko SUZUKI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Haruyuki ARIGA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Nobuharu OSHIMA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Kimihiko MASUDA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Yoshinori MATSUI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Hideaki NAGAI
Respiratory Department, National Hospital Organization Tokyo National Hospital
Atsuhisa TAMURA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Shinobu AKAGAWA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Emiko TOYODA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Kazuko MACHIDA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Atsuyuki KURASHIMA
Respiratory Department, National Hospital Organization Tokyo National Hospital
Hideki YOTSUMOTO
Respiratory Department, National Hospital Organization Tokyo National Hospital

Keywords: Chronic hepatitis, Hepatitis Cvirus, Drug-induced hepatotoxicity (DIH), Anti-tuberculosis chemotherapy, Antituberculosis drugs, Tuberculosis

JOURNAL FREE ACCESS

2008 Volume 83 Issue 1 Pages 13-19

DOI https://doi.org/10.11400/kekkaku1923.83.13

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Abstract

[Objectives] To investigate retrospectively the incidence of drug-induced hepatitis (DIH) caused by antituberculosis drugs including isoniazid (INH), rifampicin (RFP), with and without pyrazinamide (PZA), and to evaluate risk factors for DIH in tuberculosis patients complicated with chronic hepatitis (CH).
[Materials] On e hundred and seven tuberculosis patients with CH (M/F-= 96/11, mean age ± SE, 60. 8 ± 1. 4 yr) admitted to our hospital during 1998-2006, whose laboratory data had been followed before and at least 2 months after starting antituberculosis chemotherapy, were enrolled in this study. Of these, 58 were being treated with anti-tuberculosis chemotherapy consisting of INH, RFP and PZA (HRZ group) and the remaining 49 with INH and RFP (HR group). For a casecontrol study, patients admitted to the hospital during the same period and without CH were selected to each CH patient (n=107) of the same gender, the same treatment regimens, and the same age. Clinical diagnosis of CH was based on laboratory data and in some cases pathological findings; etiology of CH was C-CH (CH caused by hepatitis C virus) in 68 patients, B-CH (CH caused by hepatitis B virus) in 23, and alcoholic CH in 16.

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