An Isomerization Inside a Self-Assembled Capsule

Abstract

Stabilization of reaction intermediates is a characteristic property of enzymes, and widely regarded as an essential feature of catalytic activity. Reactive molecules can also be stabilized by encapsulation, a process that involves completely surrounding and isolating the reactive species within synthetic receptors. Here, we show that self-assembled capsules can amplify and stabilize molecules that are present in only trace concentrations in solution. Evidence is given that reversible chemical reactions take place within the capsule. Reversible encapsulation allows the direct observation of the stabilized molecules under ambient conditions, at equilibrium in the liquid phase. The system promises applications in amplification of high-energy species with reduced entropies.