Abstract
Recently, we have discovered the significantly enhanced clickability of doubly sterically-hindered aryl azides. In this poster presentation will be discussed the differences in reactivity among various azides in metal-catalyzed or metal-free click reactions to develop sequential multi-click reaction by discriminating the the type of azido groups. Our study has shown that sterically-hindered aromatic azido group remains almost intact in Ru-catalyzed cycloaddition with an alkyne. Futhermore, the difference in reactivity between aromatic and aryl azides has been examined in detail.
