Synthetic study of biselides

Abstract

Biselides A-E were isolated from the Okinawan ascidian by our group. Biselides A and B showed cytotoxic activities against various human cancer cell lines. Recently, we achieved the total synthesis of haterumalides NA and B, which are analogues of biselides. We planned to synthesize biselides A, B and E from a common intermediate of haterumalides. In here, we report synthetic study of biselides by using the regioselective allylic oxidation or the lipase-catalyzed deacetylation to introduce hydroxy group at C20 position of biselides.