Cooperative Supramolecular Polymerization with Nucleation-Elongation Process based on Allosteric Function

Abstract

We previously reported successful application of hydrindacenediamide receptor toward cooperative supramolecular polymerization driven by the positive allosteric binding. The initial dimerization of the monomer molecule, which consists of the receptor and two pendant resorcinol units, activates the receptor units for the subsequent monomer bindings by the inherent allosteric effect. This would lead to the formation of cooperative supramolecular polymers. Herein, we prepared monomers with hexaamide-type receptor, which shows an allosteric binding behavior with highly amplified 2nd binding constant. The dilution experiments of a monomer solution showed a supramolecular polymerization with critical point between monomer and polymer.