Structures and catalytic properties of zinc-included hemicryptophane

Abstract

We recently synthesized a hemicryptophane composed of a CTV, tren and rigid phenyl spacers. We also synthesized zinc-included hemicryptophane which possessed a zinc(II) within the cavity. In this study, we reported the structure of zinc-included hemicryptophane and kinetic studies of MPC hydrolysis. In particular, a direct comparison between the zinc-included hemicryptophane and the model complex, which lacks a cavity, demonstrated that the cage structure enhanced the catalytic activity.