Abstract
In the synthesis of natural products, recently there are many investigations for construction of highly oxygenated and complex bicyclo[3.3.1]nonene and bicyclo[4.3.1]decene systems.At first, as a model experiment, we conducted stepwise reaction to construct the bicyclic core. Michael addition-elimination between cyclohex-2-enone derivative and 2-acetoxymethyl-acrylic acid ethyl ester gave a cyclization precursor to followed by cyclization with potassium carbonate and tetrabutylammonium bromide to generate the bicyclic compounds.In the second place, we tried to obtain same bicyclic compounds by the one-pot reaction in the same conditions. Consequently, the one-pot reaction afforded the same bicyclic products in low yield.
