Co-host: The Chemical Society of Japan, The Society of Synthetic Organic Chemistry, Japan (Cooperation)
Recently we succeeded in the synthesis of thermodynamically unstable anti-apicophilic pentacoordinate spirophosphorane with a Martin ligand to the corresponding O-apical stable isomer. But, the p-Me O-equatorial compound is easily isomerized. Therefore, we synthesized o-C6H5C(Li)(C2F5) 2OLi. The dilithiated compound was successfully used for synthesis of O-equatorial p-Me compound. Although the p-Me O-equatorial compound is stable at room temperature, it was isomerized to its stable isomer with O-apical arrangement upon heating. Kinetic measurements for the isomerization were carried out by 1H NMR to determine the activation parameters of the isomerization. Moreover, the synthesis of hexacoodinate phosphate bearing the ligand will be discussed.
