シリカゲルブレンステッド塩基触媒によるドミノマイケル反応：ビシクロ[2.2.2]オクタン-2,5-ジオンの合成

萩原 久大; 福島 正和; 遠藤 悟; 星 隆; 鈴木 敏夫

doi:10.11494/kisoyuki.55.0.87.0

55th Symposium on Organic Reactions

Session ID : P61

DOI https://doi.org/10.11494/kisoyuki.55.0.87.0

Conference information

Co-host: The Chemical Society of Japan, The Society of Synthetic Organic Chemistry, Japan (Cooperation)

Sustainable Domino Michael Reaction Catalyzed by a Bronsted Base on Silica gel: Synthesis of Bicyclo[2.2.2]octane-2,5-dione Derivatives

Hisahiro Hagiwara, *Masakazu Fukushima, Satoru Endou, Takashi Hoshi, Toshio Suzuki

Author information

Keywords: Domino Reaction, Michael Reaction, Silica gel anion, Heterogeneous base

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Domino Michael reaction of 2,6,6-trimethyl-cyclohex-2-ene-1,4-dione and its derivatives with Michael partners have been effected to give bicyclo[2.2.2]octane-2,5-dione derivatives by a catalytic amount of Bronsted base generated from silica-gel and n-BuLi.

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