Deterioration of Retinopathy After Starting Interferon Therapy for Chronic Hepatitis C with Diabetic Triopathy.

Abstract

A 62-year-old man was administered pegylated interferon α-2a and ribavirin for chronic hepatitis C. He had come to our hospital for treatment of chronic hepatitis C and diabetic triopathy. After diet and insulin therapy blood glucose levels (HbA1c ; 6.0-6.8%, glycosylated Alb ; 18.5-20%) were adequately maintained for a year. However, AST and ALT levels ranged from 50 to 60 mU/ml by ursodeoxycholic acid and Stronger Neo-Minophagen C. Although liver function improved after interferon and ribavirin combination therapy, visual acuity decreased due to diabetic retinopathy deterioration. After the end of interferon and laser photocoagulation therapy, visual acuity improved.