A Clinical Study of 10 Cases of Kikuchi's Disease

Abstract

Background : Kikuchi's disease (KD) is a benign disease in young adults, and we studied its clinicopathological characteristics. Method : From April 2004 through October 2012, 10 cases of KD were diagnosed. Their clinical manifestations and pathological findings were studied. Results : There were 6 male and 4 female cases. The ages were 17 to 45 years old, with a median of 32. Nine cases had only one-sided cervical lymphadenopathy without spontaneous pain. Fever was observed in 7 cases. The titer of LDH was slightly elevated but that of CRP was in the normal range in 8 cases. Pathological findings of lymph nodes showed many large lymphoblasts, plasmocytoid dendric cells, and histiocytes containing fragments of karyorrhectic nuclear debris. Polymorphonuclear leukocytes were absent. Conclusions : We should pay attention to KD when a patient has lymphadenopathy on one side of the neck with fever in young adults, and must perform lymph node biopy to differentiate from malignant lymphoma.