Abstract
A single injection of clomiphene citrate could not induce ovulation in vivo as well as in vitro experiments, in the range of dosages administered. Estradiol markedly inhibited HCG-induced ovulation in the intact, hypophysectomized and the in vitro experiments.
However, the suppressive effect of estradiol on HCG-induced ovulation was apparently removed by the addition of clomiphene to the intact, hypophysectomized and the in vitro experiments.
It is proposed that clomiphene has an antiestrogenic activity at the ovarian level in Xenopus laevis.
