EFFECTS OF CENTRAL NEUROTROPIC DRUGS ON CINCHOPHEN-INDUCED GASTRIC LESIONS IN RATS

Abstract

Sodium cinchophen was administered intraperitoneally in doses ranging from 20 to 50mg/ 100g body weight to adult male Holtmman rats. There occurred motor ataxia, somnolence, irritability, spasm, hyperglycemia, eosinopenia, hypothermia and acute hemorrhagic erosions in the glandular stomach. The dose of 40mg/100g body weight was found to be most useful for experimental study of gastric lesions.
Luminal, Dazepam, Chlordiazepoxide, Morphine, Hydroxyzine and Cyiproheptadine proved effective preventing the production of gastric lesions. Therefore, it is suggested that the middle typothalamic area plays a vital role in producing the cinchophen gastric lesions in the rat. The effects of these cetral neurotropic drugs on the gastric lesions did not necessarily correlated with those of the symptoms following cinchophen admiuistraton.