Abstract
African clawed toads (Xenopus laevis) were immunized with Salmonella flagella and their immune response was studied comparing with that in mice. Antibody was produced slowly. The titer of serum antibody reached a plateau 3 weeks after the immunization and no remarkable decrease in antibody titer was observed even 20 weeks after the immunization.
There were at least 2 types of antibody; the one being heat-stable and 19S antibody type, and the other heat-labile and 7S antibody type. Both antibodies were found to be inactivated by the treatment with 2-mercaptoethanol. This fact strongly suggested that the heat-labile antibody of 7S type in African clawed toad was different from 7S IgG in mammalians.
